Multiple sclerosis is one of the best-documented indications for medical cannabis. Nabiximols (Sativex®) is approved in Germany for moderate to severe spasticity.
Note: This article is for general information and does not replace medical advice. For health questions, please consult a doctor.
## What is Multiple Sclerosis?
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. The immune system mistakenly attacks the myelin sheath of nerve fibres, creating lesions that disrupt nerve conduction. MS affects around 2.8 million people worldwide, approximately 280,000 in Germany.
## Sativex® – the First Approved Cannabinoid MS Medication
Nabiximols (trade name Sativex®) is an oromucosal spray delivering THC and CBD in a 1:1 ratio. In Germany it has been approved since 2011 for moderate to severe spasticity in MS patients who have not responded adequately to other anti-spastics.
Clinical trials (CAMS 2003, MUSEC 2012, MOVE 2 2014) demonstrated significant reductions in spasticity scores. Around 40% of patients are good responders, defined as ≥20% improvement on a Numerical Rating Scale.
## Beyond Spasticity: Pain, Bladder and Sleep
Evidence also supports cannabinoid use for neuropathic pain, overactive bladder (with significant reductions in incontinence episodes) and sleep disturbance in MS patients.
## Summary
MS is one of the best-documented indications for medical cannabis. Sativex® is the only approved cannabinoid-based MS medication in Germany. MS patients should discuss the options with their neurologist.
> Note: This article provides information about current evidence and does not replace medical advice.
About this article
Written and reviewed by the BlattWerk e.V. editorial team — licensed cultivation association in Hildesheim. Our articles are based on current legislation, scientific publications and our practical experience as a Cannabis Social Club.
Last updated: 2026-06-17 · Found an error or something missing? Let us know
Related Articles
Medical Cannabis in Germany
From prescription through indications to insurance coverage: a comprehensive guide to medical cannabis in Germany since the 2017 legislative change.
The Endocannabinoid System Explained
CB1 and CB2 receptors, anandamide, 2-AG and their role in the nervous system, immune defence, pain regulation and mood: the body's own cannabinoid system explained.
Cannabis in Pain Therapy: Evidence and Practice
Chronic pain, neuropathic pain, fibromyalgia, and migraine – an evidence-based overview of efficacy, dosing, interactions, and clinical practice of cannabinoid-based pain therapy.
Cannabis and Medications: Important Drug Interactions
CYP450 enzymes, interactions with blood thinners, antidepressants, benzodiazepines, opioids, antiepileptics, and more: a practice-oriented guide for safely combining cannabis with medications.